The author defines the concept of method and the characteristics of the scientific method in the health sciences and also how should apply to clinical research. It describes the validity, reliability, as key conditions in a measurement. The warmth of the inference from certain populations analyzes and discusses the concept of validity in inference processes as well as the random error or errors such as defects in the internal validity. After clarifying the purpose of an investigation, the author discusses the types of possible research and analyzes it. Also it defines the concept of translational research and examines the main challenges the authors After defining the concept of clinical epidemiology explain your interest and applicability in clinical practice.
Analyze the features of the process and perform a clinical analysis pointing out the importance of variability in the clinical observations and their sources of variation.
They characterize the measures used in the observation and define the different types of variables.
They point out the features that are diagnostic tests used in clinical about the value that can be added to the diagnostic presumption.
Address the criterion of prevention in clinic and its different levels, as well as the levels of recommendation to evaluate a prevention study.
They define the quality of the evidence provided by each type of study.
Later they concerned how provide quality judgments forecasts, types of studies to be carried out and appropriate epidemiological assessment (fees)
Address the quality of the studies that measured therapeutic indications (efficiency, effectiveness, efficiency) and end by quantifying the uncertainty and risk, pointing out useful measures to this effect.
It classifies the potential bias of generic and delves into the lack of accuracy, what would be the random error. Finally it describes potential sources of variability and its measurement.