Course instructors are responsible for the course content descriptions in English.
Introduction to pharmacokinetics. Compartmental, non-compartmental, and physiological approaches. Compartmental models: of 1 and 2 compartments in intravenous administration (bolus and perfusion) and extravascular in single and multiple doses. Dosage individualization and monitoring. Non-linear kinetics. The pharmacological response in pharmacokinetics.
The content of these subjects contributes to both the pharmaceutical care profile (hospital, outpatient or community) as the investigator or regulatory agencies involved. In the health care and health professional pharmacist contributes to improving the quality of life of patients through the use of safe and effective drugs stable. In the context of a health team pharmacist in collaboration with the physician and other medical staff is responsible for selecting Pharmacotherapy optimize the dose and dosage interval appropriate, preparing the medication, providing information and monitoring the occurrence of adverse effects and then establishing appropriate recommendations. This requires solid knowledge of Biopharmaceutics and Pharmacokinetics. In the field of research and development of new drugs and formulations appropriate selection of candidates with optimal pharmacokinetic properties is essential to avoid failures in the clinical stage and the rational development of it and finally the regulatory field report assessing the pharmacokinetic any new substance is an essential part of the registration and evaluation of bioequivalence studies.
Competencies and learning outcomes
- Hypothesize, assess information, and promote viable solutions to cases and professional situations.
- Ability to analyze, evaluate, and assess individual and group situations, identify problems, interpret data, and formulate solutions to individual and/or group problems.
- Assess information critically and apply the scientific method to improve the profession.
- Ability to update, consolidate, and integrate new knowledge to improve the profession using continuous self-learning techniques and critical analysis.
- Capability to use and promote innovation and creativity to solve professional problems.
- Evaluate the therapeutic and toxic effects of pharmacologically active substances.
- Design, prepare, supply, and dispense medicines and other health products of interest.
- Perform standard laboratory procedures, including the use of scientific equipment for synthesis and analysis, including proper instrumentation.
- Apply computational and data processing techniques in conjunction with information about physical, chemical, and biological data.
- Understand the properties of cell membranes and drug distribution.
- Understand the processes of liberation, absorption, distribution, metabolism, and excretion of drugs and factors that condition absorption and disposition according to the administration routes.
- Schedule and correct drug dosages based on their pharmacokinetic parameters.
- Understand the physical, chemical, and biopharmaceutical properties of the primary active ingredients and excipients and the possible interactions between them.
- Understand the stability of active ingredients and pharmaceutical forms as well as the methods of study.
- Determine the bioavailability, assess the bioequivalence, and the factors that condition them.
Objectives (Learning outcomes)
- 01Understand the processes that determine the entry of drugs into the body and its transit through (Absorption, Distribution, Metabolism and Excretion).
- 02Know the factors that affect the bioavailability of drugs (release of drug from the dosage form) and the factors that modulate the different routes of administration.
- 03Knowing the potential relationships between plasma concentrations and therapeutic response
- 04DescribING by mathematical models LADMER processes
- 05Get the pharmacokinetic parameters of a given drug from the plasma concentration-time curves
- 06Conveniently use pharmacokinetic models to predict the evolution of the drug in the body
- 07Make use of pharmacokinetic parameters to establish appropriate dosing regimens
Association between objectives and units
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Methodology and grading
- For the evaluation of the subject, it is divided into two parts:
1) Theory-Problems (80% of the grade for the course). 5 points Theory; 5 points Problems
2) Practical sessions (20% of the grade for the course).
1. Evaluation of the theory-PROBLEMS PART: an examination will be conducted on the date to be announced in the virtual classroom. The examination includes multiple-choice questions and true-false type and numerical problems and issues. The test is approved or suspended in whole.
2. ASSESSMENT OF THE PRACTICES: Students who have attended all practices in their respective group and delivered exercises that are required for their development, will conduct the exam consisting of short essay questions and multiple choice questions. The student is still entitled to a practical examination of computer lab and the day of the final exam (previously requested)
NOTE: The overall grade of practices (laboratory and computer) is saved during one academic year.
3. GLOBAL ASSESSMENT:
A) Students who pass the course: The overall assessment is always calculated as the note of each and every part of the subject is equal to or greater than five. The final grade for the course will consist of 80% of the THEORY-PROBLEMS PART OF 20% SHARE OF LABORATORY AND COMPUTER SESSIONS.
B) Students who fail the course: Only will be examined in July-PROBLEMS theoretical part of the course students who have APPROVED the other part of it; (Laboratory sessions and computer science). The remaining students will be examined in July ENTIRE COURSE
In addition, students can perform two types of activities for which the evaluation will be used to raise the note in the theoretical part. I.e. this score can not be used to get approved if not to raise the note from it. It may elect up to 0.5 additional points in the overall score.
Examinations online. To be announced in the virtual classroom and test type will be explained on the matter until its completion.
Work in Poster format and oral presentation will be exhibited at the end of the course in a session / sessions announced in mid-course. Work will be done on problem cases proposed by the teacher and exposure will be assessed by the teacher based on criteria to be announced in advance.
Students must register the first month of class into groups of maximum 5 students.
The subjects proposed and materials necessary for its realization will be presented in the web page
Each group must decide the subject of the work and notify the teacher.
Works will be presented graphically as a poster at the end of the teaching classes and each group will have 10 minutes for their presentation and defense.
The poster should clearly include the equations used for resolution, calculations and data sources used.
For the evaluation of the oral presentation a template available in advance in the virtual classroom will be used. The evaluation will be done by the teacher.