UMH - ADVANCES IN THE STUDY OF NEURONAL COMMUNICATION: FROM THE CELLULAR LEVEL TO THE COMPLETE ANIMAL

Contents

ADVANCES IN THE STUDY OF NEURONAL COMMUNICATION: FROM THE CELLULAR LEVEL TO THE COMPLETE ANIMAL

Course

Code: 1339

Degree: Master's in Neuroscience: from Research to the Clinic

Faculty of Medicine

Year: Year 1 of Master's in Neuroscience: from Research to the Clinic

Semester: Fall

Type: Required

Language: English

ECTS credits: 6

Lecture: 6

Laboratory: 0

Hours: 150

Directed: 60

Shared: 16

Autonomous: 74

Subject matter: Functional Neuroscience Concepts

Course instructors are responsible for the course content descriptions in English.

Description

Electrical signaling in the nervous system.
- Ionic currents and action potential.
- Voltage-dependent conductance.
- Coding of the electrical signal.
- Ionic channels and transporters.
Intracellular signaling.
- General principles of cell signaling.
- Nitric oxide as a signaling molecule in the nervous system.
- Regulation of nucleocytoplasmic transport of proteins.
- Neuronal functional regulation by protein kinases and phosphatases.
- Regulation of gene-expression and protein synthesis.
- Role of calcium in cell signaling.

Faculty

Name	Coordinator	Lecture	Laboratory
SALA PLA, SALVADOR	■	■	■
REIG GARCIA, RAMON		■	■
MESEGUER VIGUERAS, VICTOR MANUEL		■	■
BARCO GUERRERO, ANGEL		■	■
GONZALEZ ALVAREZ, ALEJANDRO		■	■
LOPEZ-ATALAYA MARTINEZ, JOSE PASCUAL		■	■
PEREZ OTAÑO, ISABEL		■	■
DE LA PEÑA GARCÍA, ELVIRA MARIA		■	■
VIANA DE LA IGLESIA, FELIX		■	■
CABEDO MARTI, HUGO		■	■
GUTIERREZ PEREZ, LUIS MIGUEL		■	■
VALDEOLMILLOS LOPEZ, MIGUEL ANGEL		■	■

Competencies and learning outcomes

General competencies

Understand the molecular and cellular mechanisms underlying the normal functions of the nervous system.
Learn the basics about normal human behavior, its alterations, and changes occurring during ageing.
Using macroscopic, microscopic, molecular, and electrophysiological methods recognize the nervous system's structure and function.

Specific competencies

Understand the functional bases of neuronal excitability.
Describe the cellular and molecular bases of neuronal communication and signaling.
Manage the concepts relating to biophysical, cellular, and regulatory mechanisms of synaptic communication.
Understand the main diagnostic tests used in clinical neurophysiology.
Evaluate radiosurgery and stereotactic surgery methods in the treatment of neurological diseases.
Describe the molecular and cellular bases of synaptic establishment, consolidation, and plasticity.
Describe the different ways of processing in the cerebral cortex.
Evaluate how anatomical and functional connectivity of the nervous system is analyzed and how it is reorganized under normal and pathological conditions.
Understand the basics about microscopic and macroscopic imaging techniques in neuroscience.

Objectives (Learning outcomes)

To understand the properties of ionic channels.
To know the electrical properties of excitable cells.
To know the principles of intracellular signalling by second messengers.
To know the mechanisms of nucleus-cytoplasmic communication.

Teaching units

Basic bibliography

Purves, Dale. "Neuroscience". Sunderland (Massachusetts) Sinauer cop. 2008.
Purves, Dale. "Neuroscience". Sunderland (Massachusetts) Sinauer Associates 2012.

Methodology and grading

Grading

The students will receive a numerical grade. Assistance to all the sessions is mandatory. Absence to a session has to be notified by e-mail to the instructor and the coordinator of the course (felix.viana@umh.es; elvirap@umh.es). The evaluation of the students will be based on the following aspects:

Assistance to the class sessions
Active participation in the theoretical and practical sessions
Solving the assigned homework, based on tutorials from the software “Neurons in Action 2”. The homework assignments will be presented during the introductory class.
A written exam. The exam will consist of short questions based on the content of the lectures. Some questions could be a problem, requiring basic calculation, or the analysis of a graph or data from a research paper.
To pass the course, the students need to score at least a 5 (on 0 to 10 scale) in the written exam.

Visitors: ADVANCES IN THE STUDY OF NEURONAL COMMUNICATION: FROM THE CELLULAR LEVEL TO THE COMPLETE ANIMAL

General competencies

Specific competencies

Objectives (Learning outcomes)

Lecture topics

Teaching units

Course contents

Basic bibliography

Complementary bibliography

Links

Software

Grading