UMH - TOXICOLOGY AND PHARMACOLOGY

Contents

TOXICOLOGY AND PHARMACOLOGY

Course

Code: 3620

Degree: Master's in Biotechnology and Bioengineering

Faculty of Experimental Sciences

Year: Year 1 of Master's in Biotechnology and Bioengineering

Semester: Fall

Type: Elective

Language: Spanish

ECTS credits: 3

Lecture: 2

Laboratory: 1

Hours: 75

Directed: 30

Shared: 15

Autonomous: 30

Subject matter: Biomedical Biotechnology and Bioengineering

Module: Elective

Course instructors are responsible for the course content descriptions in English.

Description

Interaction of living beings with xenobiotics. Risk assessment of chemical substances for human health. Pharmacology. Clinical toxicology. Low dose toxicity.

Faculty

Name	Coordinator	Lecture	Laboratory
ESTEBAN MOZO, JAVIER	■	■	■
PEIRO PEIRO, ANA MARIA		■	■
HERNANDEZ BLASCO, LUIS MANUEL		■	■
PENA PARDO, MARIA DE LOS ANGELES		■	■
ZAPATER HERNANDEZ, PEDRO		■	■
PELLIN MIRA, MARIA DE LA CRUZ		■	■
BARRIL ANTUÑA, JOSE RAMON		■	■
VILANOVA GISBERT, EUGENIO		■	■
ESTEVEZ DOMENECH, JORGE		■	■
HORGA DE LA PARTE, JOSÉ FRANCISCO		■	■
SOGORB SÁNCHEZ, MIGUEL ANGEL		■	■

Professional interest

Xenobiotics, exogenous chemicals without endogenous biological function, can trigger both beneficial and adverse responses, so their applications range from the pharmaceutical field to the treatment of pests, among many other uses in technological applications. Hence, the professional field of Toxicology and Pharmacology is wide and diverse, from research to chemical safety in public administrations, international agencies and industry.

Competencies and learning outcomes

General competencies

Apply acquired knowledge to resolve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to biotechnology and bioengineering.
Ability to integrate knowledge and handle the complexity of making judgments based on information that, although incomplete or limited, includes reflections on social and ethical responsibilities linked to the application of knowledge and judgments on biotechnology and bioengineering.
Ability to communicate conclusions and the knowledge and latest rationale that sustain them to specialized and non-specialized audiences in a clear and unambiguous manner.
Develop the capacity to continue studying in a mostly self-directed or autonomous manner.
Capacity to manage and organize information.
Have the ability to design and propose experiments in biotechnology and bioengineering.
Be able to critically assess and discuss information.
Be capable of coming up with new ideas to address problems related to biotechnology and bioengineering.

Specific competencies

Knowledge and skills in the use of the most common basic and advanced experimental techniques in the field of biotechnology and bioengineering and their applications for solving specific problems in this area.
Demonstrate skills to quantify phenomena and processes in biotechnology and bioengineering.
Be able to critically interpret and discuss results published and/or disseminated in journals, at conferences, and in other scientific forums.
Technical and scientific competence to ensure the achievement of accurate and reproducible results from which valid conclusions can be drawn in the scientific area of specialization within the field of biotechnology and bioengineering.
The ability to design a research project using the scientific method, compiling and evaluating information critically to resolve problems in biotechnology and bioengineering.
The ability to transfer knowledge of biotechnology and bioengineering to finding effective industrial, therapeutic, or preventive interventions, preparing the application request for a patent for a biotechnological invention.

Objectives (Learning outcomes)

To know the main environmental contaminants
To recognize the toxicological risk for long-term exposure at low doses of chemicals
To understand the mechanisms of action of drugs of abuse and psychotropic drugs
Understanding the mechanisms of interaction of neurotoxic substances with carboxylesterases as enzyme targets
To evaluate models of interaction of neurotoxic substances with carboxylesterases
Explain the concept of alternative method to animal testing
To identify if a protocol complies with the 3Rs
To know the different phases of the development of a particular active substance
To evaluate the development of a particular active substance
To develop the information sheet and informed consent document of the patient

Teaching units

Basic bibliography

Casarett, Louis J. / Doull, John 1923- / Klaassen, Curtis D. "Casarett and Doull's toxicology the basic science of poisons". New York McGraw-Hill c2008.

Methodology and grading

Methodology

Case studies: Learning through the analysis of actual or simulated cases in order to interpret and resolve them by employing various alternative solution procedures.
Lecture: Pass on knowledge and activate cognitive processes in students, encouraging their participation.
Problem-based learning: Develop active learning strategies through problem solving that promote thinking, experimentation, and decision making in the student.
Solving exercises and problems: Exercise, test, and apply previous knowledge through routine repetition.

Grading

The contents will be evaluated by "continuous evaluation", "written exams" and "reports".

Final score = Attendance (25%) + Toxicology score (50% through completion of 7 tasks) + Pharmacology score (25% through written and oral tests each day).

Assessment test characteristics

Correction criteria

The course will be passed with a minimum score of 5 out of 10.

Visitors: TOXICOLOGY AND PHARMACOLOGY

General competencies

Specific competencies

Objectives (Learning outcomes)

Lecture topics

Teaching units

Course contents

Basic bibliography

Complementary bibliography

Links

Software

Methodology

Grading

Assessment test characteristics

Correction criteria

Additional requirements